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Figure 7


Fig. 7. Evidence for coupling of Lrp6 functions: inhibition of Wnt/PCP signaling and activation of Wnt/ß-catenin signaling. (A) In contrast to Lrp6, injection of a mutant Lrp6 that cannot activate the Wnt/ß-catenin pathway (LRP6-m5) does not inhibit activin-mediated elongation of animal caps. Equivalent amounts of lrp6 or lrp6-m5 mRNA (2 ng) were injected. (B) lrp6-B mRNA (3 ng) alone does not induce secondary axis formation in Xenopus embryos, but potentiates the activity of wnt8 mRNA (6 pg) in secondary axis assays. Numbers of embryos injected are shown in parentheses. Asterisk indicates statistically significant differences (P<0.01). (C) Model in which Wnt ligands promote assembly of active Lrp6/Frizzled (FZ) receptor complexes that recruit Dishevelled and actively inhibit Wnt/PCP signaling (via as yet unknown mechanisms) through the B domain of Lrp6.





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