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Figure 2


Fig. 2. SHP-2 activity is required for the maintenance of expression of cardiac markers. (A-D) Cardiac explants isolated and cultured in DMSO or NSC-87877 beginning at stage 22. In situ hybridization performed on explants with probes specific for Nkx2.5 (A), Tbx5 (B), Tbx20-(C) and MLC1v' (D) at stages 22, 26, 29 and 33, as indicated. Black arrows denote Tbx5 expression at the leading edge of the cardiac ridge at stage 33. (E) In situ hybridization of Nkx2.5 in uninjected (control) or Shp-2 N308D-injected explants treated with DMSO or NSC-87877 beginning at stage 22, and assessed at stage 37. (F) In situ with Nkx2.5 of anterior region of whole Xenopus embryos cultured in DMSO (control) or NSC-87877. H, heart; P, pharyngeal arches.





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