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Figure 4


Fig. 4. SHP-2 is required for cardiac cell survival. TUNEL staining of control cardiac explants (DMSO) and explants treated with NSC-87877. Cell death examined in explants at stages 22, 26, 29 and 33, as indicated. Red arrows denote cardiac cells, yellow arrows endodermal cells. Double in situ (red)/TUNEL (dark blue) using a Tbx5-specific probe on stage 26 explants that were cultures in DMSO or NSC-87877 from stage 22-26. Black arrow points to Tbx5-expressing cells in NSC-87877-treated explants.





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