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First published online October 26, 2007

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FGF keeps segmentation clock ticking

The segmented pattern of the vertebrate spine is established during embryogenesis by the formation of somites (blocks of mesoderm that form the vertebrae and back muscles) at regular temporal intervals. In the clock and wavefront model for somitogenesis, pulses of Notch, FGF and Wnt signalling in the presomitic mesoderm (PSM) are translated into the periodic array of somites at the so-called wavefront. Olivier Pourquié and colleagues now provide the first genetic evidence that FGF signalling positions the wavefront and controls the segmentation clock in mouse somitogenesis (see p. 4033). They show that conditional deletion of the FGR receptor gene Fgfr1 in the mesoderm abolishes FGF signalling and disrupts normal cyclic gene expression in the PSM. It also arrests somite formation. In addition, pharmacological inhibition of FGF signalling blocks the oscillations of both Wnt and Notch signalling in the PSM, but with different kinetics. The researchers conclude, therefore, that FGF signalling acts upstream of Wnt and Notch signalling to control the segmentation clock during mouse somitogenesis.

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Related articles in Development:

FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis

Matthias B. Wahl, Chuxia Deng, Mark Lewandoski, and Olivier Pourquié
Development 2007 134: 4033-4041. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?