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First published online October 26, 2007

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Wired for smell

The mouse olfactory system, which detects numerous environmental chemical stimuli, is divided into subsystems. Sensory neurons in each subsystem within the olfactory epithelium have different receptor molecules and project their axons to different parts of the olfactory bulb. Now, on p. 4063, Peter Mombaerts and colleagues report that semaphorin 3F (Sema3f) and its co-receptor neuropilin 2 (Nrp2) are involved in the axonal wiring of guanylate cyclase-D (GC-D⁺)-expressing sensory neurons. The axons of these neurons, which are not known to express odorant receptors, project to the necklace glomeruli, which sit between the main and accessory olfactory bulbs. To visualize the axonal projections of GC-D⁺ neurons, the researchers generated mice that co-express GC-D with labelled tau (an axonal marker). They show that in Sema3f-null (but not Sema3b-null) mice and Nrp2-null mice, GC-D⁺ neurons form ectopic glomeruli in the main olfactory bulb, as well as the necklace glomeruli. Thus, the researchers conclude, an Nrp2-Sema3f interaction helps to determine the axonal wiring of this relatively poorly studied olfactory subsystem.

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Related articles in Development:

Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F

Andreas Walz, Paul Feinstein, Mona Khan, and Peter Mombaerts
Development 2007 134: 4063-4072. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?