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Figure 3


Fig. 3. Roles of MEF2 in Drosophila muscle development. (A) In the early mesoderm, MEF2 expression is activated by Twist, and MEF2 regulates downstream genes involved in cell migration, signaling and founder cell identity. (B) During differentiation of the somatic muscle lineage, Lame duck (LMD) activates MEF2 expression in a subset of muscle cells. DPP also regulates MEF2 expression via Twist and MAD/Medea. During late myogenesis, MEF2 autoactivates its own expression. MEF2 regulates hundreds of genes involved in contractility, neuromuscular junction formation, myoblast fusion, ion transport and metabolism. (C) In the developing dorsal vessel, MEF2 is regulated by GATA factors, Tinman, and by an as yet unidentified bHLH factor. MEF2 is essential for the expression of genes involved in cardiac contractility.





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