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Figure 3


Fig. 3. Pitx2 expression is asymmetric during gonadal development. (A) Pitx2 expression between E2 and E12. (i) E2 (HH13) transverse section across the posterior part of the somitic region showing asymmetric expression of Pitx2 in the left splanchnic and somatic lateral plate mesoderm. (ii) At E3 (HH20), Pitx2 is asymmetrically expressed in the left gonadal region and weakly in the mesonephros. (iii) At E4.5 (HH25), Pitx2 asymmetric expression is maintained in the left side of the dorsal mesentery and in the adjacent gonad, but is lost in the mesonephros. (iv-vi) Pitx2 expression is maintained in the left gonad of both sexes at HH31(E7), HH36(E10), HH38(E12). (B) Pitx2c expression in left gonad and mesentery (E5; HH26). (C) Pitx2 expression in E7 (HH31) gonads from samples injected with lindane. An embryo with complete situs inversus expresses Pitx2 in the right gonad (i), whereas three out of four embryos with gut heterotaxia express Pitx2 bilaterally (ii) and one only in the left gonad (iii). IM, intermediate mesoderm; LPM, lateral plate mesoderm; L, left; R, right; LG, Left gonad; RG, right gonad; Me, mesentery; Ms, mesonephros; So, somite. Scale bars: 100 µm.





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