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Figure 4


Fig. 4. Krm promotes LRP6-mediated Wnt signaling. (A-D) TOPFLASH luciferase reporter assays in HEK293T cells. Co, empty pCS2 vector. (A) XKrm1 cooperates specifically with LRP6. (B) Co-transfection of mesd and Xkrm1. (C) BMP luciferase reporter assay in HEK293T cells. (D) Effect of XKrm1 on LRP6 signaling is Dkk1-dependent. RLU, relative light units.





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