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Figure 1


Fig. 1. Neurogenesis and hair cell production coincide in the otic epithelium. (A) Temporal-spatial relationships between neurogenesis (cyan) and sensory epithelial differentiation (beige). Activity levels are schematized in color above the time-line. Ut, utricle; Sac, saccule. (B) E11.5 otocyst (rotated from A) with NeuroD domain (cyan) and Math1 expression (beige hatching) highlighted. pUt, presumptive utricle; pSac, presumptive saccule. (C) Part of the early inner ear labyrinth at E13.5, defined by the red box, shown on same scale as B. Orientation and color codes are as in B. Math1 expression in the anterior and lateral cristae is shown in dark gray. (D) NeuroD (cyan) and Math1 (beige) epithelial expression domain areas versus developmental stage. (E) Epithelial NeuroD+ cell number versus developmental stage. (F) Alternating serial sections through the presumptive (E11.5) and definitive (E14.5) utricle, hybridized for NeuroD or Math1. Arrow indicates early Math1 expression. (G-J) Math1-GFP reporter tissue double-labeled with NeuroD antisense RNA (red) and anti-GFP antibody (green). In G, triple arrowheads and arrow indicate lateral and medial stripes of Math1-GFP, respectively, as illustrated in B. In H and I, arrowheads and bracket indicate spatial overlap of the two markers. Arrowheads in J indicate the border of Math1-GFP and NeuroD expression. Axes in F apply to F-J. Scale bars: 50 µm.





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