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Figure 2


Fig. 2. Fate mapping identifies Ngn1 derivatives in the VIIIth ganglion and ear epithelium. (A-F) Structures from E16.5 (A) or E14.5 (B-F) Ngn1-CreER;Z/EG embryos, double-stained for transgenic GFP (green, Ngn1 derivatives) and myosin VIIa (red, sensory hair cells). ac, anterior crista; ger, greater epithelial ridge; lc, lateral crista; oC, organ of Corti, pc, posterior crista; poC, presumptive organ of Corti; sac. m., saccular macula; sp. g. spiral ganglion; ut. m. utricular macula; ut. non-sens, utricular non-sensory; vest. g., vestibular ganglion. Arrows in E and inset indicate Ngn1 derivatives in non-sensory tissue between the lateral crista and utricular macula. (G) Summary of Ngn1 derivatives in the ear. Gray areas represent sensory structures lacking Ngn1 derivatives. (H-K) Ngn1 derivative cell phenotypes (green) in sensory maculae. Red label is myosin VIIa in H,I and phalloidin in J. Arrowhead in I indicates a double-positive cell. In K, arrowheads indicate supporting cells; asterisks indicate hair cells.





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