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Figure 5


Fig. 5. Ngn1 negatively autoregulates and interacts with the Notch pathway. (A-D) Ngn1-GFP BAC transgene expression in a wild-type E10 otocyst (A), wild-type E12.5 utricle (B), Math1-/- E14.5 utricle (C) and Ngn1-/- E12.5 utricle (D). Arrowheads in A indicate delaminating cells with stronger GFP signal than their neighbors. (E,F) Dll1 expression in wild-type and Ngn1-/- otic epithelia at E11.5. pUt, presumptive utricle; pSac, presumptive saccule. (G,H) Ngn1 mRNA expression in wild-type and Pofut-/- embryos at E9. Insets show the invaginating otic epithelium. Arrowheads and arrows (insets) indicate Ngn1 mRNA signal in the otic epithelium, outlined with dotted white line. o, otic epithelium; mb, midbrain; t, trigeminal placode; ep, epibranchial placode; sp, spinal cord.





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