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Fig. 4. ARF6 is required for rapid growth of the plasma membrane during cytokinesis. (A) Representative cells for control, arf6 early regressor and chic^13E cells illustrate perimeter kinetics during anaphase and cytokinesis. (B) Rate of perimeter change in control, arf6 early and late regressors, and chic^13E cells. Membrane insertion is significantly impaired in arf6 from 5 min AA onwards: ^*P<0.05 and ^#P<0.001, Student's t-test. Membrane insertion is not significantly impaired in chic^13E mutants until central spindle disassembly (cf. 5-10 min AA with 10-20 min AA). Error bars represent s.e.m. (C) Timeline of the events of cytokinesis and the rates of cytokinesis furrow ingression and perimeter change (membrane growth) in control and arf6 early regressors, with respect to central spindle Pav-GFP appearance. Black and white bars represent 1-minute intervals. CS, central spindle; CR, contractile ring.

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