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Figure 4


Fig. 4. Intrinsic Sema3A cell-autonomously sets the growth cone sensitivity to exogenous Sema3A. (A) Histogram showing the percentage of EGFP+ or EGFP- collapsed growth cones of Sema3AiresEGFP or control EGFP ventral spinal cord explants following exposure to Sema3A or control supernatant. Axons were counted from at least three independent experiments. ***, P<0.001 with X2 test; n.s., non significant. (B) Morphology of ctrlEGFP+ (collapsed) or Sema3AiresEGFP+ (non-collapsed) axons emerging from ventral spinal cord explants after Sema3A supernatant exposure. (C) Comparison of the collapse response (%) of pShScramble-EGFP+, pShScramble-EGFP-, pShSema3A-EGFP+ and pShSema3A-EGFP- axons following exposure to decreasing doses of Sema3A. *P<0.01 with X2 test between pShSema3A-EGFP+ and all other conditions. At least 150 growth cones from two embryos were examined in each condition.





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