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Figure 7


Fig. 7. Model of action of intrinsic Sema3A. (A) Mode of action of intrinsic Sema3A, showing that Sema3A expressed in neurons inhibits the response of their growth cones to environmental Sema3A through regulation of cell availability of Nrp1 (NP1). Predominant autocrine effect of neuronal semaphorin is indicated with an arrow. (B) Mechanism of interplay between intrinsic and extrinsic Sema3A in the development of motoneuron projections. Nrp1+ LMC axons are guided ventrally by the repulsive effects of Sema3A expressed in the DRG, the notochord and the dermamyotome. MMC axons are attracted dorsally by cues including ephrinA5 and FGFs. Intrinsic Sema3A in Nrp1 + MMCm neurons decreases their sensitivity to environmental repulsion by Sema3A, which enables their axons to project dorsally but to avoid the DRG and the dermamyotome.





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