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First published online November 26, 2007

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Membrane recycling: not an ARFterthought

During cytokinesis, the central spindle microtubules and the actomysin contractile ring drive dramatic cell shape changes. These shape changes also involve a rapid increase in the plasma membrane surface area, but how is this achieved? Dyer and colleagues propose that the endosomal trafficking component ARF6 promotes rapid membrane addition during spermatocyte cytokinesis in Drosophila (see p. 4437). The researchers show that cytokinesis fails in most meiotic divisions in arf6-null spermatocytes. They use time-lapse microscopy to show that the rapid addition of membrane to the plasma membrane is defective in these spermatocytes and causes furrow regression. In normal spermatocytes, they report, ARF6 is enriched on recycling endosomes at the central spindle and binds to the centralspindlin component Pavarotti. However, ARF6 is not required for central spindle or actomysin contractile ring assembly or for targeting of recycling endosomes to the spindle. They propose, therefore, that ARF6 promotes the rapid recycling of endosomal membrane stores during cytokinesis, thus coordinating membrane recycling with central spindle formation.

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Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes

Naomi Dyer, Elena Rebollo, Paloma Domínguez, Nadia Elkhatib, Philippe Chavrier, Laurent Daviet, Cayetano González, and Marcos González-Gaitán
Development 2007 134: 4437-4447. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?