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Fig. 1. Identification of a candidate svs mutation in a non-recombinant
interval. (A) Block diagram showing the number of each chromosome
type isolated in crosses between svs M. mus musculus and wild-type
M. mus castaneus mice. Meiotic chromosomes typed for phenotypic and
molecular loci are depicted as columns of blocks. White and black blocks
indicate the presence of the M. mus musculus allele (svs strain) or
the M. mus castaneus allele, respectively. The number of chromosomes
observed with each genotype is shown at the top of the column (from a total of
222 informative chromosomes analyzed). Mapped loci are indicated on the left.
(B) Genetic and physical maps of the svs candidate interval. The svs
mutation maps between D7Mit134 and D7Mit43 on mouse chromosome 7 (top). In the
NCBI m34 mouse genome sequence assembly
(Waterston et al., 2002), this
genetic interval corresponds to a 410.3 kb physical interval. Annotation of
the genome sequence reveals the presence of two known and six predicted genes
in this candidate interval (bottom) (Birney
et al., 2006).
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