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Figure 4


Fig. 4. Dramatic alterations in alternative splicing of Fgfr2 in svs mutant mice. (A) FGFR2 is represented by a schematic of its protein domains with the corresponding exons numbered below each domain. The bar below the diagram indicates the location of the in situ hybridization probe used in Fig. 3. (B) The transcript structure of the 19 different isoforms of Fgfr2 identified in svs mutant and wild-type seminal vesicles, along with the number of times each transcript was found and the percentage of all isoforms identified in parentheses. The complete sequence of each transcript is available from GenBank with accession numbers EF143322-EF143340. Abbreviations: Ig, Immunoglobulin-like; AB, acid box; TMD, transmembrane domain; TK, tyrosine kinase domain; 8b/c, exon 8IIIb or 8IIIc.





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