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Fig. 6. Restoration of spermatogenic defects in Scmh1-/-
testes by Phc2 mutation. (A) Restoration of morphological
defects in Scmh1-/- testes by Phc2 mutation.
(B) Restoration of fertility in
Scmh1-/-;Phc2-/- mice. Results from
ten mice with respective genotypes were summarized. (C) Significant
reduction of apoptotic outbursts in
Scmh1-/-;Phc2-/- testes compared with
Scmh1-/- single mutants. (Left) Incidence of apoptosis was
examined in wild-type, Scmh1-/- and
Scmh1-/-;Phc2-/- testes at day 19 pp
by TUNEL staining. (Right) Three hundred seminiferous tubules derived from
five mice with respective genotypes were analyzed for the presence of
TUNEL-positive cells and the results were summarized. (D) Restoration
of spermatocytes, in which dimethylated H3-K9 was enriched at the XY body in
Scmh1-/-;Phc2-/- testes (left).
Frequency of spermatocytes, in which dimethylated H3-K9 was accumulated on the
XY body, was summarized (right). (E,F) Frequency of
spermatocytes, in which monomethylated H3-K9 was enriched at (E) and
phosphorylated pol II was excluded from (F) the XY body in
Scmh1-/-;Phc2-/- testes was
compared.
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