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First published online January 10, 2007

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Neural crest cells set free by BMP

Neural crest (NC) cells are progenitors that delaminate away from the neural tube once specified. An epithelial to mesenchymal transition is required in these cells before dispersal can occur. These cells then migrate to new locations where they form the peripheral neurons and glia, in addition to several other cell types. On p. 491, Kalcheim and colleagues show how BMP4 promotes the ADAM10-mediated cleavage of N-cadherin along the neural tube, thus alleviating the inhibitory effect of N-cadherin on NC delamination. Full-length N-cadherin protein inhibits NC delamination by promoting cell-adhesion mechanisms and by repressing Wnt signalling, which acts downstream of BMP4 and is required for delamination. Mutation analysis revealed that N-cadherin has three domains - the ß-catenin, extracellular and juxtamembrane domains that are required for correct NC delamination. Interestingly, overexpression of the N-cadherin soluble cytoplasmic cleavage product stimulates both ß-catenin and cyclin D1 transcription, leading to enhanced Wnt signalling and NC delamination.

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Related articles in Development:

Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination

Irit Shoval, Andreas Ludwig, and Chaya Kalcheim
Development 2007 134: 491-501. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?