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First published online January 10, 2007

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LRP6: axing axin

The LDL receptor-related protein 6 (LRP6) was first identified as a Wnt co-receptor in mice. However, the precise role that LRP6 plays in Wnt signalling has remained unclear. On p. 503, Janet Heasman's group now reveal that LRP6 degrades axin - an essential event in the Wnt11-activated formation of the dorsal axis in Xenopus embryogenesis. They also reveal that LRP6 regulates axin levels in the oocyte and maintains ß-catenin expression in a low steady state - Wnt signalling has previously been believed to exist in either an on or off state. Axin is a negative regulator of Wnt signalling that targets ß-catenin for degradation, so preventing Wnt target gene activation. LRP6 depletion in the embryo, in this study, led to increased axin and decreased ß-catenin levels. In wild-type oocytes, exogenous ß-catenin degradation was prevented by the co-injection of LRP6 mRNA, whereas in axin-depleted oocytes, ß-catenin levels increased. This study reveals a novel role for LRP6 in axin degradation and highlights the complexity of Wnt signalling.

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Related articles in Development:

Wnt11/ß-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin

Matt Kofron, Bilge Birsoy, Douglas Houston, Qinghua Tao, Christopher Wylie, and Janet Heasman
Development 2007 134: 503-513. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?