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Fig. 4. Axon growth and guidance defects in the developing
Fz3-/- and Celsr3-/- central nervous
system. (A) Anti-neurofilament staining of horizontal sections
through E15 WT and Fz3-/- mouse brains shows a complete
absence of thalamocortical and corticothalamic fiber bundles in an otherwise
normal-appearing Fz3-/- forebrain; the normal location of
these fibers is indicated by an arrowhead. (B) DiI tracing of
commissural axons in E11 WT and Celsr3-/- mouse spinal
cords shows a failure of rostral turning by Celsr-/- axons
after midline crossing. The spinal cord has been opened at the dorsal midline
and flattened (an `open book' preparation). DiI was placed in commissural cell
bodies beyond the left edge of each image. The vertical white line indicates
the midline. A, Anterior/rostral; P, posterior/caudal. Panel A is reproduced
with permission from Wang et al. (Wang et
al., 2002) and panel B is courtesy of Drs Libing Zhou and Andre
Goffinet.
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