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Fig. 5. Hair follicle orientations on the back of WT and
Fz6-/- mice at P0 and P4. (A-D) Posterior is to
the right. The scatter plots show the angles of each hair follicle shaft (the
region closest to the skin surface) and base (the region furthest from the
skin surface) with respect to the anterior-posterior axis (set at zero degrees
and corresponding to the central point along each axis). (A,B) WT follicles at
P0 have orientations that range from
-45 to +45 degrees, a distribution
that narrows by P4. (C,D) Fz6-/- follicles at P0 have
random orientations, which by P4 have partially reoriented to produce spatial
domains with imperfect local order. Additional reorientation continues over
the next several days (see Fig.
2C for follicle orientation at P8). In both WT and
Fz6-/- skin, the distribution of shaft angles tightens
more than that of bulb angles. Scale bar, 400 µm. Reproduced with
permission from Wang et al. (Wang et al.,
2006c).