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Figure 5


Fig. 5. Hair follicle orientations on the back of WT and Fz6-/- mice at P0 and P4. (A-D) Posterior is to the right. The scatter plots show the angles of each hair follicle shaft (the region closest to the skin surface) and base (the region furthest from the skin surface) with respect to the anterior-posterior axis (set at zero degrees and corresponding to the central point along each axis). (A,B) WT follicles at P0 have orientations that range from ~ -45 to +45 degrees, a distribution that narrows by P4. (C,D) Fz6-/- follicles at P0 have random orientations, which by P4 have partially reoriented to produce spatial domains with imperfect local order. Additional reorientation continues over the next several days (see Fig. 2C for follicle orientation at P8). In both WT and Fz6-/- skin, the distribution of shaft angles tightens more than that of bulb angles. Scale bar, 400 µm. Reproduced with permission from Wang et al. (Wang et al., 2006c).





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