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Figure 3


Fig. 3. Defects in AV boundary formation in both the Hesr1- and Hesr2-misexpressing heart. Chamber identities were examined by whole-mount in situ hybridization of E9.5 embryos. Hand1 (A-C) and Irx4 (D-F) were used as markers for the ventricular chamber. Cx40 (G-I) was used to demarcate both the atrial and ventricular chambers. Boundaries between the chambers and AV canal are less evident in the Hesr1-ME heart (B,E,H) and appear to be lost in the Hesr2-ME heart (C,F,I), as compared with the wild-type embryo (A,D,G). The bracket in D indicates the AV canal (AVC) and the arrowheads in E,F,H,I indicate the AV boundaries for the atrium and/or ventricle.





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