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First published online January 26, 2007

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Silence please for MRG-1

Germ cells are unique in their ability to give rise to the next generation, and thus must remain undifferentiated to maintain totipotency. Mammalian mortality-factor-related MRG15 is a chromodomain protein that regulates transcription. The C. elegans orthologue of MRG15 is MRG-1, and now Hiroshi Sakamoto's and Susan Strome's labs (see p. 757) report that MRG-1 is required for germline development and for X chromosome silencing in C. elegans. Surprisingly, however, MRG-1 localizes only to autosomes and is undetectable on X chromosomes. MRG-1 shares with the maternal-effect sterile protein, MES-4, an autosomal localisation and the ability to repress genes in the germ line. However, MRG-1's autosomal localisation does not depend on MES-4 activity, and vice versa. MRG-1 might, the authors propose, act in a complex to modify chromatin organisation and gene expression through the regulation of histone acetylation. They further suggest that MRG-1 might de-repress autosomal genes that can silence genes on the X chromosome; these autosomal genes, however, have yet to be identified.

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Related articles in Development:

MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans

Teruaki Takasaki, Zheng Liu, Yasuaki Habara, Kiyoji Nishiwaki, Jun-ichi Nakayama, Kunio Inoue, Hiroshi Sakamoto, and Susan Strome
Development 2007 134: 757-767. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?