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Figure 5


Fig. 5. catp-1 specifically interacts with the daf-2/InsR branch of the dauer pathway to control dauer formation and morphogenesis. (A) Aberrant morphogenesis of catp-1(kr17) dauer larvae induced by exposure to dauer pheromone. Compared with wild-type dauer larvae (upper row), catp-1(kr17) dauer larvae are short (left), with a constricted pharynx (middle), and are trapped in their L2 cuticle (right, arrowheads). Scale bar: dissecting scope, 50 µm (left); Nomarski microscopy, 10 µm (middle and right). (B) Schematic representation of the dauer pathway, adapted from Beckstead and Thummel (Beckstead and Thummel, 2006), Gerisch and Antebi (Gerisch and Antebi, 2004) and Riddle (Riddle and Albert, 1997). (C) Genetic interactions between catp-1(kr17) and mutants of the dauer pathway: dauer formation at 25°C scored by visual inspection. age-1(mg44), daf-7(e1372) and daf-9(dh6) are null alleles. The arrow points to the suppression of constitutive dauer formation in catp-1(kr17); daf-2(m41). * defective dauer morphogenesis. Error bars represent s.e.m. (n≥3 independent experiments, N≥89 individuals). (D) Aberrant morphogenesis of catp-1(kr17); daf-2(m596) dauer larvae. catp-1(kr17); daf-2(m596) dauer larvae (bottom row) are short with a constricted pharynx which appears squeezed in the head (left), abnormal alae (middle) and normal small gonads (right). Scale bar: 10 µm.





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