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Figure 7


Fig. 7. DAF-2 and CATP-1 interact with the Ras-MAPK signaling pathway. (A) Dauer formation at 25°C scored by visual inspection. Error bars represent s.e.m. (n≥3 independent experiments, N≥72 individuals). let-60(n1046) partially suppresses daf-2(m41) but not daf-2(e1370) constitutive dauer formation (*P<0.05, Mann-Whitney test). (B) Survival on 0.75 mM DMPP. Error bars represent s.e.m. (n≥3 independent experiments, N≥136 individuals). mek-2(n1989), and ksr-1(n2526) are significantly more DMPP resistant than N2. let-60(n1046) strongly suppresses catp-1(kr17) and daf-2(m41) DMPP resistance (*P<0.05, **P<0.005, Mann-Whitney test).





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