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Figure 8


Fig. 8. A genetic model for CATP-1 action in L2 developmental timing and dauer formation. (A) Control of L2 developmental timing. CATP-1 speeds up both a cell division and a molting timer independently of the UNC-63/nAChR and DAF-12/NHR pathways described in Ruaud and Bessereau (Ruaud and Bessereau, 2006). daf-2 mutant DMPP resistance probably results from a similar developmental delay and involves both the DAF-16/FOXO and Ras-MAPK pathways. CATP-1 effect on developmental timing likely involves a Ras-MAPK branch of the daf-2 pathway. Whether catp-1 directly interferes with daf-2/InsR, modulates Ras/MAPK activity and/or functions through a third unidentified parallel pathway remains equally possible at this stage. Dashed lines: hypothetical interactions. (B) Dauer formation. In addition to the DAF-16/FOXO and DAF-12/NHR pathways, DAF-2/InsR controls dauer formation through a Ras-MAPK pathway. CATP-1 is likely to modulate dauer formation by negatively interacting with this Ras-MAPK branch, but could also directly alter daf-2/InsR signaling or work through an uncharacterized parallel pathway (see the text for a full discussion).





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