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Fig. 4. Nuclear reorganisation at and around Hoxd during ES cell
differentiation. (A) Histograms showing the distribution of 2D FISH
hybridisation signals for the Hoxd (green), Lnp (yellow) and 3' flank
(RP23-7D13, red) BACs relative to the edge of the MMU2 CT during
differentiation. Arrowheads show the median positions for each probe.
(B) Mean±s.e.m. position (µm), relative to the edge of the
MMU2 CT for the hybridisation signals from the Hoxd, Lnp and 5' and
3' flanking BACs during the timecourse of differentiation. (C)
Distribution of interphase separation (d) in µm, measured between
hybridisation signals for the Lnp and Hoxd BACs (black bars), or between the
5' flank and the Lnp BAC (white bars) during the first 8 days of
differentiation. Black or white arrowheads indicate the median separation
between each probe pair. (D) Mean±s.e.m. interphase separation
(d), in µm, measured between four pairs of probe signals (as indicated)
during the timecourse of differentiation. For all experiments,
n>100 loci.
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