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Figure 5


Fig. 5. vari is required for accumulation of Verm and Serp in the tracheal lumen. (A-E) Lumenal secretion and accumulation of the putative matrix modifying protein Verm is disrupted in vari (B-D) and other SJ mutants such as Lac (E). Notably, in some mutants such as vari3953b and Lack11012b, Verm accumulates in the cytoplasm (arrows in C and E). vari3953b mutants show variable expressivity of the Verm secretion defect, with some animals showing extensive cytoplasmic Verm accumulation (C) and others showing little (D). (F-H) Lumenal accumulation of the Verm-related protein Serp is defective in vari and Lac mutants, but in contrast to Verm, Serp is completely absent in vari and Lac mutants, including in the hypomorphic vari3953b allele. Scale bar: in H, 2.5 µm for A-H.





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