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First published online February 9, 2007

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New interactions WAVE plants along

In plants and animals, the shape of many cells is controlled by the actin-nucleating ARP2-ARP3 complex, which itself is regulated by a multimeric complex that includes SCAR/WAVE (suppressor of cAMP receptor/Wiskott-Aldrich syndrome protein-family verproline-homologous protein). Now, on p. 967, Martin Hülskamp and colleagues provide new details about cell-shape control in plants. In Arabidopsis, they report, SCAR proteins seem to be direct effectors of small Rac-like GTPases called ROPs (Rho proteins of plants); by contrast, in animal cells, SCAR activity is indirectly regulated by RAC1. The researchers show that AtSCAR2 (one of five Arabidopsis SCAR homologues) activates the ARP2-ARP3 complex in vitro and that plants mutant for AtSCAR2 have a similar phenotype to those mutant for ARP2 or ARP3. They then used yeast two-hybrid analysis and bimolecular fluorescence complementation to construct a proteininteraction network between the ROPs, the SCAR/WAVE complex and the ARP2-ARP3 complex. This network confirms many of the protein interactions previously identified in animals, but, note the researchers, it also reveals several new interactions.

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The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis

Joachim F. Uhrig, Moola Mutondo, Ilona Zimmermann, Michael J. Deeks, Laura M. Machesky, Philipp Thomas, Silke Uhrig, Claudia Rambke, Patrick J. Hussey, and Martin Hülskamp
Development 2007 134: 967-977. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?