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First published online February 9, 2007

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APC doubles up to regulate female meiosis

Meiosis, the specialised two-stage cell division that produces eggs and sperm, involves a significant reorganisation of the canonical cell-cycle machinery. Swan and Schüpbach have been studying this important developmental change to this machinery and now report that two anaphase-promoting complexes - APC^Fzy and APC^Cort - cooperate during female meiosis in Drosophila (see p. 891). During mitosis, the E3 ubiquitin ligase APC and the adaptor protein Fzy target cyclins for destruction during anaphase. By examining various single and double mutants, the researchers reveal that Cort, a diverged Fzy homologue expressed in the female germline of Drosophila, functions with Fzy to drive anaphase in meiosis I and II. Both adaptors, they show, control global cyclin destruction but also the local destruction of spindle-associated cyclin B during meiosis II. The researchers suggest, therefore, that during female meiosis in Drosophila, the germline-specific APC^Cort cooperates with the more general APC^Fzy to target cyclins for destruction and allow progression through the two meiotic divisions.

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Related articles in Development:

The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila

Andrew Swan and Trudi Schüpbach
Development 2007 134: 891-899. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?