spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 4


Fig. 4. Linking PAR polarity to contractile polarity: CDC-42. Illustrations of C. elegans embryos: (A) wild type; (B) depleted of CDC-42; (C) expressing a PAR-6-{Delta}CRIB mutant; (D,E) depleted of Rho early (D) and late (E) in the first cell cycle. The acto-myosin network (pink) is indicated from a surface view of the embryo cortex; CDC-42 (purple dashed line) and PAR-6 (red) are shown in the embryo mid-plane. Embryo anterior, or the meiotic pole in C, is to the left. Embryos lacking CDC-42 or the CDC-42-binding CRIB domain of PAR-6 have reduced cortical localization of PAR-6, indicated by the dotted red line in B and C. Both PAR-6 and CDC-42 remain uniformly distributed around the cortex despite asymmetry of the acto-myosin network in rho-1(RNAi) embryos late in the cell cycle (E), suggesting that CDC-42 cannot respond to the acto-myosin network when Rho signaling is disrupted.





Right arrow Return to article