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Figure 11


Fig. 11. A model of Jagged/Notch regulation of cell-type specification in the pronephros. Early in pronephric cell differentiation (8-10 hpf), cells expressing high levels of Jagged 2 interact locally with Notch3-expressing cells to inhibit the expression of rfx2 and jagged 2. Jagged 2/Notch3 signaling requires the E3 ligase mind bomb, and initiates regulated intramembranous proteolysis (RIP) of Notch3 and the liberation of the transcriptionally active Notch3 intracellular domain (N(3)ICD). N(3)ICD activates expression of unknown repressors (?), which downregulate rfx2 (and downstream cilia genes) and jagged 2. Later in development (assayed here at 34-56 hpf), a subset of cells becomes multiciliated and N(3)ICD-mediated transcriptional regulation in neighboring cells directly or indirectly regulates the expression of ion channel genes and allows these cells to acquire a transporting-epithelial-cell fate.





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