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Figure 3


Fig. 3. Cortical lamination defects and hippocampus-like cytoarchitectonic transformations. (A-K) Nissl-stained adult wild-type, TgS/L, TgS and TgL coronal forebrain sections at rostral (A,D,G), mid (B,E,H) and caudal axial levels, in low (C,F,I) and high (J,K) magnification views. Note the compact hippocampus-like pyramidal cell layer in subicular (Sub) and retrosplenial areas (Rsc) in TgS, TgS/L and TgL brains (arrows in F,I,K). (L,M) Nissl-stained adult wild-type and TgS transgenic horizontal sections showing that the subicular pyramidal cell layer in the Zbtb20 transgenic mice is transformed into a compact hippocampus-like pyramidal cell layer in TgS (arrow in M). aq, aqueduct of Sylvius; cc, corpus callosum; Cgc, cingulate cortex; DG, dentate gyrus; M, motor cortex; S, somatosensory cortex; Str, striatum (caudate putamen); 3V, third ventricle; V, visual cortex.





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