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Fig. 7 . p75 upregulation in the SVZ-RMS of NCAM-/- animals
is accompanied by the presence of abnormally mature neurons. (A)
Western blot analysis of p75 expression in WT and NCAM-/- brain.
p75 is expressed at higher levels in the RMS-OB of NCAM mutant mice during
early postnatal life. *, P<0.05 (two-tailed unpaired
t-test). (B) Confocal image of sagittal brain slices stained
for p75 and doublecortin (DCX) demonstrating the presence of small round
p75+ DCX- cells in the WT SVZ-RMS (arrows).
p75+ cells occasionally form small clusters (insert). (C)
Immunolabeling for p75 in NCAM-/- brains revealed an increased
number of p75 cells in the SVZ-RMS. These cells often exhibited a branched
morphology (arrowheads). A higher magnification image of the area depicted in
the left-hand panel illustrates that most of these p75+ cells
colocalized with the neuronal marker doublecortin. Scale bars: 20 µm.
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