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Figure 4


Fig. 4. Enhanced neurogenesis and altered adhesive properties after activation of transgenic Pax6 in developing cortex. (A,A') The E13.5 JoP6;Emx1IREScre VZ is significantly diminished as compared with JoP6, but the size of the Tuj1+ mantle zone (M) is unchanged. Also, premature differentiated Tuj1+ cells are found ectopically in the VZ of JoP6;Emx1IREScre at E14.5 (B,B') and E11.5 (C,C'). (D) q-PCR of total RNA from control and JoP6;Emx1IREScre cortices normalized to 18S RNA. N-CAM and R-cadherin are upregulated, whereas Pxn, Tnc, Itgb3 and Itga5 are downregulated. Error bars indicate s.d.





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