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First published online March 9, 2007

Development 134, 706e (2007)
© The Company of Biologists Limited
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In this issue

Shrooming into shape


Figure 1

Cell shape changes brought about by, for example, apical constriction and apicobasal elongation, are a common feature of morphogenesis. But, although the basis of apical constriction is becoming clearer, the molecules that govern apicobasal elongation remain a mystery. Now, on p. 1431, John Wallingford and colleagues report that Shroom3 - an actin-binding protein - is required for the apicobasal elongation of neuroepithelial cells during Xenopus neural tube closure. Surprisingly, Shroom3 redirects the apical distribution of the microtubule (MT) regulator {gamma}-tubulin, causing apicobasal MT arrays to form, although how {gamma}-tubulin interacts with MTs in this setting is unknown. Since Shroom3 is already known to act in apical constriction, it now appears to be required for both types of neuroepithelial cell shape change during neural tube closure. Shroom1 is also shown to direct {gamma}-tubulin redistribution, revealing a conserved function for Shroom proteins. By combining their data with those of earlier studies, the authors propose a model in which epithelial cell shape changes, but not polarity, depend on Shroom3.


Related articles in Development:

Shroom family proteins regulate {gamma}-tubulin distribution and microtubule architecture during epithelial cell shape change
Chanjae Lee, Heather M. Scherr, and John B. Wallingford
Development 2007 134: 1431-1441. [Abstract] [Full Text]  




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