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Figure 1


Fig. 1. Schematic of vertebrate lens development. (A) Morphogenesis of the lens begins when the evaginating optic vesicle (OV), which derives from the neuroectoderm (NE, blue), contacts the head surface ectoderm (HSE, yellow). (B) Upon this contact, the HSE thickens and forms a lens placode (LP). (C,D) The optic cup subsequently forms the retina (R) and the lens placode invaginates and forms a lens vesicle (LV). (E) Once the vesicle is formed, the lens cells in the posterior half of the vesicle elongate and form the lens fiber cells (LF). By contrast, the cells in the anterior of the lens vesicle remain as a monolayer and form the anterior lens epithelium (ALE). Modified with permission from Lovicu and McAvoy (Lovicu and McAvoy, 2005).





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