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Figure 5


Fig. 5. Snail2 modulates neural crest EMT in a Cad6B-dependent fashion. Explantation and 4-hour culture of chick neural folds electroporated in vivo with an equimolar mixture of either (A) the Snail2 MO plus control MO or (B) the Snail2 MO plus Cad6B MO. (C) Bar chart showing s.e.m. of explantation results. Statistical analysis identifies a significant reduction in the number of neural crest cells undergoing EMT in the presence of Snail2 MO when compared with the Snail2 MO plus Cad6B MO (P<0.0001; unpaired Student's t-test). 13% of emigrating neural crest cells from Snail2 MO-treated explants are Snail2 MO-positive, suggesting the requirement of Snail2 to ensure proper EMT (n=32 explants). 51% of emigrating neural crest cells contain both the Snail2 and Cad6B MOs, demonstrating that neural crest EMT occurs via a mechanism that involves repression of Cad6B by Snail2 (n=36 explants).





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