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Fig. 2. Wnt/ß-catenin pathway is activated in the AFB of
Hesx1-/- mutants at early somite stages.
(A,B) Rostral view of the Wnt1 expression domain in
wild type (A) and Hesx1-/- mutant (B) at the 3- to
4-somite stage. Wnt1 transcripts do not reach the rostral tip of the
NP in wild-type embryos, but do so in Hesx1-/- mutants
(arrowhead). (C-F) Frontal (C,D) and lateral (E,F) views of the
Fgf8 expression domain in wild type (C,E) and
Hesx1-/- mutant (D,F) at the 4- to 5-somite stage.
Fgf8 expression in the anterior neural ridge (ANR) is reduced in the
Hesx1-/- mutant. Arrowheads in C,D indicate the posterior
limit of the Fgf8 expression domain in the ANR. (G,H)
Expression of the Wnt/ß-catenin target Axin2 in wild type (G)
and Hesx1-/- mutant (H) at the 3- to 4-somite stage.
Dorsal view, anterior is to the bottom. Note the expansion of the
Axin2 expression domain in the Hesx1-/- mutant
(H). Arrowheads indicate the rostral limit of Axin2 expression.
(I-N) Dorsal (I-L) and lateral (M,N) views of the expression domain of
the Wnt/ß-catenin target Sp5 in wild type (I,K,M) and
Hesx1-/- mutant (J,L,N) at the 5- to 6-somite (I,J) and
the 2- to 3-somite (K-N) stages. Anterior is to the bottom (I-L) or to the
left (M,N). Note the expansion of Sp5 expression throughout the
anterior NP in the Hesx1 mutant (J,L,N). Only the most rostromedial
region of the NP is free of Sp5 transcripts (arrowheads indicate the
rostral limit of Sp5 expression).
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