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Fig. 6. Genetic rescue of the forebrain defects in the Hesx1- deficient embryos. (A,B) 12.5-dpc wild-type (A) and Hesx1^Cre/Cre (B) embryos. Note the small telencephalic vesicle and the absence of the eye in the mutant embryo (B). (C,D) 12.5-dpc Hesx1^Cre/Cre;R26^Cond-Hesx1/+ compound embryos. Note the significant rescue of telencephalic development, but very little (D) or no rescue (C) of the eye defects. (E,F) 12.5-dpc Hesx1^Cre/Cre;R26^Cond-Hesx1^/ ^Cond-Hesx1 compound embryos showing significant rescue of both telencephalon and eye development.

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