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Fig. 7. AFB patterning is improved in Hesx1^Cre/Cre;Rosa^{Cond-Hesx1/Cond-Hesx1} compound embryos. (A,B) Frontal view of the Hesx1 expression domain in wild type (A) and in a Hesx1^Cre/Cre;Rosa^Cond-Hesx1^/^Cond-Hesx1 compound embryo (B), showing comparable levels of expression. (C,D) Dorsal view of Foxd3 expression domain in wild type (C) and in a Hesx1^Cre/Cre;Rosa^Cond-Hesx1^/^Cond-Hesx1 compound embryo (D). Arrowheads indicate the region of the rostral NP where Foxd3 is not expressed. (E,F) Frontal view of Axin2 expression domain in wild type (E) and in a Hesx1^Cre/Cre;Rosa^Cond-Hesx1^/^Cond-Hesx1 compound embryo (F). Arrowheads indicate the rostral limit of Axin2 expression. Note the presence of AFB tissue that is devoid of Axin2 transcripts in E and F.

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