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Fig. 2 . Early depletion of Mi-2ß in the ventral epidermis results
in late depletion of the basal and suprabasal layers. (A)
Hematoxylin and Eosin-stained sections of WT and mutant ventral skin isolated
from E10.5-P1 stages of development. A reduced cellularity in the ventral
epidermal layers was apparent from E16.5 to P1. (B-D) Expression of
keratin 5 (K5) (basal epidermis), keratin 1 (K1) (suprabasal epidermis), and
loricrin (granular epidermis) was examined by immunofluoresence. DAPI-stained
nuclei are shown in blue. The timing of induction and expression of these
epidermal differentiation markers is not initially affected. Their progressive
reduction later in development reflects a progressive depletion of basal and
suprabasal layers. Scale bars: 50 µm.
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