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Figure 3


Fig. 3. Cardiovascular, but not other neural crest-dependent, derivatives are affected by loss of endodermal Shh. Comparison of wild-type, Nkx2.5Cre/+; Shhflox/- and Shh-/- embryos reveals that only certain NCC-derived structures depend on endodermal Shh. (A-F) Cranial nerves (CN) are relatively normal in Nkx2.5Cre/+; Shhflox/- embryos (B) compared with Shh-/- mutants (C), whereas their arch-artery patterning (E) more closely resembles Shh-/- defects (F) rather than wild-type (A,D). (G-O) Similarly, expression of the NCC markers Ap2{alpha} and CrabP1, as well as AP2{alpha} antibody, in Nkx2.5Cre/+; Shhflox/- mutants (H,K,N) resemble wild-type (G,J,M) and not the abnormal pattern seen in Shh-/- embryos (I,L,O). In all panels, arrows and arrowheads mark abnormal and normal findings, respectively, in mutants as compared with control embryos.





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