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Figure 5


Fig. 5. Morpholino knockdown of pkd2-/- causes hydrocephalus and dilations in the pronephric region in high doses. (A-C) Lateral views of 48-hpf embryos. Cross-sections of the brain (D-F) and kidney regions (G-I) at 72 hpf. The pkd2 augMO (4 ng) (C) and pkd2 SpMO (not shown) often have variably milder tail curls than that of a cuptc321 mutant (B) but noticeably different than that of a wild-type embryo (A). The embryos injected with either MO displayed hydrocephalus (F, SpMO) and dilations in the glomerular and tubular regions of the pronephros (I, SpMO) that are not observed in wild-type and cup embryos (D,E and G,H). Arrowheads indicate regions of hydrocephalus (C,F) and arrows indicate the dilations in the area of the pronephros (I). Note the smaller liver and gut tube underlying the pronephric dilations in MO-injected embryos (I).





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