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Fig. 3. Defects in migration of SCG cells in Creb-null mice.
Parasagittal sections of E15.5 mouse embryos immunostained with TH antibody
show the SCG normally shaped and located in proximity to the inner ear
(asterisk) in control (A) and CrebDBHCre;
Crem-/- mutants (B), but not in
Creb-/- mutants (F). The stellate ganglion is
located in the thoracic region in the CrebDBHCre;
Crem-/- mutant (D) and in the respective control
littermate (C) as well as in the control littermate of
Creb-/- (E). However, in
Creb-/- it extends more rostrally (F). At E17.5 a similar
pattern is found in Creb-/- showing less sympathetic
neurons in the area of the SCG (H, circled area) and more in the area
of the stellate ganglion in comparison with control (G). Black
arrowhead indicates the tubercle of the first rib, used as a positional
reference to compare the position of the stellate ganglia. Scale bar: 300
µm in A-F; 600 µm in G,H.
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