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Fig. 1. Expression patterns of Shh, Ptc1 and the Gli family
transcription factors in the developing inner ear at 11 dpc.
(A,A') Gli1 and (B,B')
Ptc1 show a graded expression pattern in the otocyst, strongest in
the ventral-medial tip of the otocyst and weaker towards the dorsal region.
Weaker hybridization signals are also found in the dorsal-lateral region of
the otic epithelium as well as in the mesenchyme. (C) Gli2 mRNA is
broadly expressed throughout the otic epithelium but its expression in the
endolymphatic duct (ed) is barely detectable. (D) Gli3 expression is
evident in the entire otocyst, with weaker expression in the dorsal-lateral
side. Both Gli2 and Gli3 transcripts are also detected in the mesenchymal
tissues, especially in the lateral region of the otocyst. Arrowheads (C,D)
indicate the margin of the otic epithelium. (E) Shh is strongly
expressed in the ventral midline structures, the floor plate (arrow) and
notochord (arrowhead), but its transcripts are not detectable in the otocyst.
vp, vertical pouch; co, cochlea; D, dorsal; L, lateral. Scale bars: in A, 100
µm for A-E; in A', 100 µm for A',B'.
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