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Figure 3


Fig. 3. Inner ears of Shh and Gli3 compound mutants. Paint-filled inner ears of (A) Shh+/-;Gli3+/+, (B) Shh-/-;Gli3+/+, (C) Shh-/-;Gli3+/-, (D) Shh-/-;Gli3-/- and (E) Gli3{Delta}699 mutants at 14.75 dpc. (B) Shh-/-;Gli3+/+ inner ears lack ventral structures, including the cochlear duct and saccule (asterisk). Dorsally, the lateral semicircular canal/ampulla and endolymphatic duct are missing. (C) The dorsal structures in Shh-/-;Gli3+/- inner ears are normal, but only a small knob-like structure is present ventrally (arrow). (D) In Shh-/-;Gli3-/- ears, the dorsal structures are malformed, and a shortened cochlear duct is present. (E) Inner ears of Gli3{Delta}699 homozygotes show normal dorsal inner ear phenotypes, yet the cochlear duct is shortened. (A',D',E') Ventral views of respective cochlear ducts. For abbreviations refer to Fig. 2; p, proximal; d, distal. Scale bar: 100 µm.





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