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Fig. 5. Inner ears of Gli2 and Gli3 compound mutants at 13.5 dpc. Lateral views of inner ears of (A) Gli2^+/-;Gli3^+/-, (B) Gli2^-/-;Gli3^-/-, (C) Shh^-/-;Gli3^-/-, (D) Shh^+/-;Gli3^-/- mutants at 13.5 dpc. (B) Gli2^-/-;Gli3^-/- inner ear has a shortened cochlear duct that is comparable to that of Shh^-/-;Gli3^-/- mutants (C). The dorsal defects shown in Gli2^-/-;Gli3^-/- inner ears are similar to those in Gli3^-/- single (D) and Shh^-/-;Gli3^-/- double mutants (C). White and red asterisks indicate the lack of anterior and lateral semicircular canals, respectively. There is a developmental delay in inner ears of Gli2^-/-;Gli3^-/- and Shh^-/-;Gli3^-/- double mutants, as indicated by the lack of resorption of the posterior semicircular canal (arrows). For abbreviations refer to Fig. 2. Scale bar: 100 µm.

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