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Fig. 6. Pn-1-deficient mice express higher levels of cyclin D1
and cyclin D2 in their cerebella. Cerebellum cortices of P10
Pn-1+/+ and Pn-1-/- mice were
homogenized and processed for immunoblot analysis. After densitometric
quantification, the protein levels were monitored relatively to beta-actin and
normalized to the Pn-1+/+ value. Both cyclin D1 (A)
and cyclin D2 (B) levels are increased in the mutant cerebellum. Values
shown represent mean±s.e.m. *P<0.05 (Student's
t-test).